The severity of SARS-CoV-2 infection is dictated by host factors? Epigenetic perspectives

The severity of SARS-CoV-2 infection is dictated by host factors? Epigenetic perspectives

Blog Article

The emergence of COVID-19, caused by SARS-CoV-2 poses a significant threat to humans as it is highly contagious with increasing mortality.There exists a high degree of heterogeneity in the mortality rates of COVID-19 across the globe.There are multiple speculations on the varying degree of mortality.

Still, all the clinical reports have indicated that preexisting chronic diseases like hypertension, diabetes, chronic obstructive In-Line pulmonary disease (COPD), kidney disorders, and cardiovascular diseases are associated with the increased risk for high mortality in SARS-CoV-2 infected patients.It is worth noting that host factors, mainly epigenetic factors could play a significant role in deciding the outcome of COVID-19 diseases.Over the recent years, it is evident that chronic diseases are developed due to altered epigenome that includes Jandy Parts a selective loss/gain of DNA and histone methylation on the chromatin of the cells.

Since, there is a high positive correlation between chronic diseases and elevated mortality due to SARS-CoV-2, in this review; we discuss the overall picture of the aberrant epigenome map in varying chronic ailments and its implications in COVID-19 disease severity and high mortality.